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Center for the Evaluation of Risks to Human Reproduction

By Shelby, Michael D., Ph. D.

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Book Id: WPLBN0000218698
Format Type: PDF eBook
File Size: 1.3 MB
Reproduction Date: 2005

Title: Center for the Evaluation of Risks to Human Reproduction  
Author: Shelby, Michael D., Ph. D.
Language: English
Subject: Government publications, United Nations., United Nations. Office for Disarmament Affairs
Collections: Government Library Collection, Disarmament Documents
Publication Date:
Publisher: United Nations- Office for Disarmament Affairs (Unoda)


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Shelby, Ph. D, M. D. (n.d.). Center for the Evaluation of Risks to Human Reproduction. Retrieved from

Government Reference Publication

Excerpt: In studies supported by Wyeth Laboratories, Protein Technologies International, and the National Institutes of Health (NIH), Setchell et al. (19) measured isoflavone levels in infant soy formula and in the blood of infants (n = 7) consuming soy formula. Results of the study, as well as additional details about methodology, were published in a later report by Setchell et al. (7). Following extraction with methanol, isoflavone levels in 5 US infant formulas were measured by high performance liquid chromatography (HPLC). Genistein and daidzein conjugates, mainly glycosides, were the most abundant isoflavone-related compounds identified. Mean percentages of isoflavones and their respective conjugates were reported at 67.1% genistein equivalents, 28.7% daidzein equivalents, and 5% glycitein equivalents in soy infant formula. Levels of individual isoflavones, based on conversion to aglycone concentrations, are included in Table 3, which summarizes the USDA survey of soy formulas. Total average isoflavone equivalents concentrations were reported at 32?47 mg/L in prepared formulas. Table 4 lists estimated intakes of isoflavones and the assumptions used to estimate exposure. Depending on infant age, isoflavone equivalents intake was estimated at 6?12 mg/kg bw/day. A comparison of estimated isoflavone equivalents intake from soy formulas available in different countries is included in Table 5, which also includes estimates of individual isoflavone equivalents levels based on mean levels detected in formula.


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